BIOL 222 Lecture Notes - Lecture 3: Membrane Transport Protein, Calcitriol, Aldosterone
Document Summary
Structure determines: how it travels in bloodstream, interacts and targets cells. Some will be free ---> cleared quickly. Hydrophobic hormone- enters the cell via diffusion (look at picture in notes) Hydrophilic- water loving, can travel easily in blood stream alone. Water loving, can travel easily in blood stream. Androgen, progesterone, estrogen, testosterone corticosteroids, calcitriol, aldosterone (sex hormones) progesterone, estrogen, testosterone. Equilibrium- as free are removed, some bound are released. Turn gene on --- transcribe and translate into protein. Thought question: because lipid derivative hormones are hydrophobic, they cannot be made ahead and stores in membrane vesicles. Why not: should not be exposed to hydrophilic environment for too long; specifically water environments, lipid derived would diffuse through the cell because they can pass through the hydrophobic membrane. Pituitary gland: antidiuretic hormone, oxytocin, prolactin, growth hormone. Glycoprotein- 200 amino acids + carbohydrate side chains. Pituitary gland: thyroid stimulating hormone, luteinizing hormone, follicle stimulating hormone. Bind outside to cell membrane receptor (protein)
