PSYC 405 Lecture Notes - Lecture 12: Apolipoprotein E, Amyloid Precursor Protein, Psen2
13 Mar 2020
School
Department
Course
Professor
Dementia
Dementia
◦Loss or decline in memory and other cognitive abilities
◦Caused by variety of diseases resulting in damaged brain cells
Decline in memory and at least one of the following
● Decline in coherent speech, spoken or written
● Decline in ability to recognize or identify objects
● Decline in performing motor activities, sensory function, and
comprehension of task
● Ability to make judgments, carry out complex tasks
● Must be severe decline that interferes with daily life
Most common type of dementia
◦Alzheimer’s disease
Accounts for 60-80 percent of cases
● Progressive, fatal disease
◦More than 5.7 million Americans have it
◦6th leading cause of death in U.S.
◦277 billion dollars/annual cost (doesn’t include costs from unpaid caregivers)
◦16.1 million unpaid caregivers for AD
Document Summary
Loss or decline in memory and other cognitive abilities. Caused by variety of diseases resulting in damaged brain cells. Decline in memory and at least one of the following. Decline in coherent speech, spoken or written. Decline in ability to recognize or identify objects. Decline in performing motor activities, sensory function, and comprehension of task. Ability to make judgments, carry out complex tasks. Must be severe decline that interferes with daily life. 277 billion dollars/annual cost (doesn"t include costs from unpaid caregivers) Transfer of information at the synapses begins to fail and. Number of synapse declines and eventually cells die. Lots of debris from dead and dying neurons. Begin in areas for learning and memory and then spread out to other areas. More than 500,000 people in their 30s, 40s, and 50s have ad or a related dementia (alzheimer"s association) Current estimate of 200,000 under 65 may have younger-onset ad. May be due to rare genetic variations involving chromosome 21.
