BCS 240 Lecture 18: 10/12 - Neurotransmitter Systems II
14 Oct 2018
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10-12 when inactive, a g protein is composed of 3 subunits ( , , and ) with a gdp molecule bound to the subunit. float around along the inside membrane until they meet a receptor activation of g proteins: G protein bumps into a activated receptor and exchanges its gdp for. Gtp (becomes active/enters a high energy state) activated g-protein splits into the g -gtp and the g subunits. G -gtp s(cid:415)mulates e ector proteins to induce a second messenger (large neurotransmitter pathway) G opens ion channels from the inside (small neurotransmi(cid:425)er pathway) G -gdp and g recombine and float around until activated again. 2. adenylyl cyclase cyclic amp (camp) protein kinase a. G i inhibits adenylyl cyclase/camp produc(cid:415)on phospholipase c protein kinase c and ip3. Ec50 concentra(cid:415)on of the drug that results in 50% of the maximum response maximally effective antagonists require a lower concentration to block an already occurring response (best mimic the inhibitory neurotransmitter)
