BIO 198 Lecture Notes - Lecture 33: Sister Chromatids, Cooperative Binding, Mitosis
22 Nov 2016
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Single stranded dna you get proteins/filaments that bind to the single stranded dna (rcca is bound a the 3" end with atp from cooperative binding- binding of subunit will encourage subsequent binding of subunits). A lot of repair mechanisms make single stranded gaps and can be coded by rcca. A single stranded dna is more vulnerable to breakage. This strand exchange is reversible and not an irreversible reaction until atp is hydrolyzed and rcca comes off. Once rcca is off and not there anymore, than it becomes permanent: There are multiple copies of origin of replication and ready to divide as soon as genome completes replication so next round of replication is already half way down. Two sister chromatids are held together and when you get a double strand break on one sister chromatid, it can be repaired with the information from the other chromatid.
