BIO SCI 38 Lecture Notes - Lecture 18: Cell Adhesion Molecule, Aplysia, Cadherin
10 Jan 2020
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Arc sustains actin regulation to allow ltp consolidation. When arc synthesis is prevented there is a corresponding large loss of new actin filaments. This supports the hypothesis that arc contributes to the consolidation of. Without arc present, the earlier increases of ampa receptors in the psd and the changes in spine size are thought to be lost. Note: changes on postsynaptic side of synapse. 1) increase in spine head volume, mediated by increased f-actin (structural protein) 2) increases in synaptic adhesion molecules (cadherin) 3) increase in ampa receptors in postsynaptic membrane. Points 1 & 2 above provide structural stability of the synapse over time. Disrupting biochemical steps impacting pathways regulating these steps disrupts ltp induction or consolidation. Some critical steps for induction and maintenance of ltp. Simultaneous glutamate binding and membrane depolarization (driven by. Structural changes in postsynaptic membrane involving actin dynamics. Changes in neuronal transcription for genes involved in late stage ltp stabilization.
