BIO SCI 38 Lecture Notes - Lecture 38: Basolateral Amygdala, Fear Conditioning, Anisomycin
10 Jan 2020
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Only the reactivated memory trace needs to be reconsolidated. However, only the reactivated memory (cs1) was disrupted by u0126, a drug that interferes with reconsolidation. U0126 is a drug that blocks the activation of map kinase. Map kinase activation is necessary for ltp. U0126 blocks consolidation of toneshock fear conditioning. One example: arc is required for the reconsolidation of pavlovian fear. Memory maddox and schafe, 2011; journal of neuroscience. Arc antisense odns in the lateral amygdala disrupted consolidation of new tone -shock fear conditioning and also the reconsolidation of tone - shock fear conditioning after a reminder (tone presentation) 275, the division between acquisition of a memory and memory retrieval is a distinction that may not be honored by the brain ; idea attributed to norman spear (1973) Maybe reconsolidation is part of a natural process to allow memory traces to be updated to incorporate new information. Memory formation and retrieval are not necessarily independent processes.
