LIFESCI 3 Lecture Notes - Lecture 5: Amide, Alpha Helix, Alpha And Beta Carbon
Document Summary
Peptide bond between carbo and amino groups = partial double bond, must stay in same plane. Backbone - carbon, nitrogen, first amino group, last carboxylic group. Does not include h of amino group, h attached to alpha carbon, side chains, oxygen of carboxyl group. Single change --> whole structure/function can be changed. Determined by peptide backbone interaction and h bonding involved. H of amino group, o of carboxylic group, side chain. Parallel vs antiparallel (in regards to n/c terminus) In aq environment (water), nonpolar fold to face inside, polar face out. Independently fold into own shape and are stable. Sequence motif - similar sequence --> similar structure --> similar function. Structural motif - diff protein w/ same structure but diff sequence. Made up of negative side chains (aspartate and glutamate) At equilibrium, calcium released --> protein straightens up and changes conformation. Calcium conc increased when sperm reaches egg and blocks other sperm from entering.
