MCD BIO 50 Lecture Notes - Lecture 24: Somatic Cell Nuclear Transfer, Allele, Nuclear Transfer

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Cloning has the potential routes that have been sought to make personalized pluripotent stem cells that are a perfect genetic match to a speci c patient, and will therefore provoke no immune rejection on grafting. To clone somethings means to make a set of identical genetic copies. Somatic cell nuclear transfer (scnt):replacement of the nucleus of a secondary oocyte by that of a somatic cell. If successful, the resulting embryo will have the genetic constitution of the donor nucleus. This a method for reproductive or therapeutic cloning of animals. An important capability possessed by an early embryo me by nuclear transfer can be used to establish an es cell line. this cell line will be genetically identical to the donor of the original nucleus, and because. Es cells can be used a s source for several therapeutically useful cell types, the cell line could serve as a source of immunologically compatible grafts for the person.

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