MCB 2210 Lecture Notes - Lecture 22: Ptk2, Focal Adhesion, Talin Protein
17 Dec 2018
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Document Summary
Hemidesmosome - cell to ecm attachment in epithelial cells. Focal adhesions - cell to ecm attachment in non-epithelial cells. Macromolecular complexes through which mechanical force and regulatory signals are transmitted. Integrins are the most prominent adhesion receptor in focal adhesion. Fibronectin in the ecm link with the intracellular actin cytoskeleton. Different integrins interact with distinct protein ligands. Humans encode 18 alpha and 8 beta subunits. Interact with ligands to aid in signaling, morphogenesis, and movement in diverse cell types. Integrins attach to actin through abps like talin and vinculin. Stress fibers are anchored to focal adhesion. Forms reflect changes in the cytoplasmic and extracellular domains of the protein. Inside-out signaling - the cytoskeleton on the inside of the cell can influence binding to the extracellular matrix. Outside-in signaling - interactions with the extracellular matrix can alter organization of the cytoskeleton within the cells. Phosphorylation of rtks influences talin to activate integrins.
