NURS 3110 Lecture Notes - Lecture 22: Vancomycin, Probiotic, Erythromycin
Document Summary
Aminoglycosides: mechanism of action, disrupt bacterial protein synthesis, 30s ribosomal subunit, activity, aerobic gram negative, do not cover anaerobic, e. coli, klebsiella pneumoniae, p. aeruginosa. E. coli is often foodborne and causes 70% of traveler"s diarrhea. Pseudomonas aeruginosa is everywhere, and often causes a. Ineffective against anaerobes blueish-green infection: moa requires transport across bacterial cell membrane. Again, discourage patients from using these topical products. Most people don"t need an antibiotic for a simple cut, and can used plain vasoline for a moisturizer. Using topical antibiotics contributes to antibiotic resistance: streptomycin is still the drug of choice for bubonic plague, which circulates on rodents and is transmitted by fleas. It is also effective for tuberculosis: tobramycin is especially effective in cystic fibrosis. Pulmonary infections are a significant factor in cf morbidity and mortality. Ototoxicity may occur long after the drug was administered: nephrotoxicity, related to cumulative dose, keep well hydrated, new regimen: high dose once/day.
