NURS 3220 Lecture Notes - Lecture 9: Lactation, Sedation, Central Nervous System Depression
Document Summary
Histamine: naturally occurring, endogenous compound, found in specialized cells in the body. Ige immunoglobulin initiates this reaction: as seen in diagram formation of. Ige interacting with the allergen in the immune system. H1 receptors: vasodilation, skin of the face and upper body, extensive: can cause hypotension. Increased capillary permeability: edema, bronchoconstriction, not the cause of an asthma attack, cns effects, role in cognition, memory and sleep-waking cycles, other. Itching, pain, secretion of mucus: secretion of gastric acid, act directly on parietal cells to promote acid release, dominant role in acid release. Histamine antagonists/antihistamines: act primarily on h1 and h2 receptors, used primarily for two pathologic states, allergic disorders, peptic ulcer disease. Allergic responses: mediated by histamine and other compounds, prostaglandins, leukotrienes, typtase. Mild allergic responses: caused largely by histamine acting at h1 receptors, rhinitis, itching, localized edema, hay fever, mild transfusion reaction, acute urticaria, usually responsive to antihistamine therapy.
