ANFS251 Lecture Notes - Lecture 30: Thrombin, Plasmin, Cytoskeleton

• School: University of Delaware
• Department: Animal and Food Sciences
• Course: ANFS251
• Professor: Griffiths Lesa

Document Summary

Necrosis (not regulated: refers to the death of cells and living tissue. It begins with cell swelling, chromatin digestion, and disruption of the plasma membrane and organelle membranes. Late necrosis is characterized by extensive dna hydrolosis, vacuolation of the endoplasmic reticulum, organelle breakdown and cell lysis: the release of intracellular content after plasma membrane rupture is the cause of inflammation in necrosis. Morphologic features: cell shrinkage with increased cytoplasmic density, chromatin condensation, phagocytosis of apoptotic cells by adjacent healthy cells. Formation of cytoplasmic blebs and apoptotic bodies: get signal, regulators down stream, activation of caspase, catabolism of cytoskeleton, apoptotic bodies. Hemorrhage: bleeding or the abnormal flow of blood, bleeding can be internal or external, too much blood loss can result in hypovolemic shock, many causes from trauma to genetic conditions (hemophilia) Like necrosis bleeding may be a clinical symptoms of a disease and part of its pathology (host pathogen interaction)