ANFS332 Lecture 12: Clonal Selection and Animal Virology
27 Feb 2018
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11:14 am: red text = important, blue text = do not need to know. In this figure, an animal was injected with antigen a at day 0. Antigen a invokes a primary response beginning about day 4, as indicated by a rise in the specific antibody titer (not that rapid) Titer = a measure of the amount of antibody in the animal"s serum per unit volume. Initially, this antibody is mostly igm. (igm and igg are classes of antibodies) A peak titer occurs between days 7 and 10, then the response decreases rapidly. Antibody kinetics: the second response (adaptive) o o. If the animal is reinjected with antigen a at day 28, the production of antibody begins almost immediately and reaches a level 1000-fold greater that that seen in the primary response. This animal has memory with respect to that antigen. Much more rapid with much higher antibody response. Only a primary response to antigen b is observed. o.
