ANSC 452 Lecture Notes - Lecture 7: Limb Bud, Somite, Hox Gene
15 Nov 2020
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Document Summary
Limbs development from mesodermae cells fat are conad in ectoderm. Outgrowth/patterning occurse a cartilage template is made. Proliferating mesoderm are progenitors for chondrocytes connective tissue. Muscle cells migri migrate from the somite, differentiate in somite. 4 somita -progenitated cells also make azide muscle. Nerve cells migrate & grow to limbs from the neural tube. Condensation results from altered adhesion & mesenchymal movesto epithelial to mediated by catherins, fibronectin, & n-cam y after different/2tlon, chondrocytes secrete cartilage ecm. At joints chondrocytes express gpf 5 to undergo apoptos, Wnt ne saues cells on either side of the joint. 4 both g dfe wnt leave persistant cartilage. 4 cartilage that will be replaced by bone expresses indian hedgehog 2 smp. Gof-s causes apoptosis, wat protects cells from apoptosis both signaling makes articular cartilage. Ansc 452 woln seven day two regions of cells. Remember that hex genes word 3 do 5 anterior to posterion developing limo.
