MCB 150 Lecture Notes - Lecture 7: Allosteric Regulation, Cytochrome C Oxidase Subunit Ii, Nitrogenous Base
1 Feb 2017
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Deviation in ph causes it to stop working. Will affect every copy of enzyme in the body. The body must make more of the enzyme. Do not have time to make enzymes before lethality. Irreversible inhibition usually comes from things outside the cell. Inhibitor molecule resembles substrate in part that binds in active site. Increase the concentration of the substrates = less inhibition and increased enzyme reaciton. Decrease inhibitor concentration = more inhibition (less enzyme activity) Cell made the inhibitor, so it can regulate the concentration of the inhibitor. Allosteric site - other site . not active site. Vioxx and other prescription nonsteroidal anti-inflammatory drugs (nsaids) are potent inhibitors of the cycloxygenase-2 (cox-2) enzyme. High substrate concentrations reduce the efficacy of inhibition by these drugs. Phosphate groups, 5 c ring, and nitrogenous base. When numbering carbon ring, use , which means prime. Monomers = deoxyribonucleotides or deoxyribonucleoside triphosphates (dntps)
