EHS 260 Lecture Notes - Lecture 30: International Diabetes Federation, Diabetes Mellitus Type 1, Insulin Resistance
![](https://new-preview-html.oneclass.com/lAX98ZbWJYdojKx4GrOaNn0grqyDPwa7/bg1.png)
Introduction
Diabetes mellitus is characterized by chronic hyperglycemia (high blood glucose concentration)
and high NEFA (non-esterified fatty acid) concentration.
Over time high blood glucose and NEFA concentrations may lead to a variety of complications
which impair quality of life and reduce life expectancy.
Type 2 Diabetes
Comprises 85–95% of diabetes in developed world.
Insensitivity to insulin (insulin resistance – for a given concentration of insulin, less glucose is
cleared from the blood cells).
Some impairment of insulin secretion.
Who develops DM-2?
Usually found in obese or overweight adults.
Was typically associated with obese adults age 40+, but is becoming much more
frequent in children
While genes play a role, 80% preventable with healthy diet and PA (International Diabetes
Federation, 2007).
Life expectancy is impaired by 5–10 years
CVD accounts for ~50% of DM fatalities
Lifetime risk of developing DM in US (born in 2000)
Males: 32.8%
Females: 38.5%
Although type 2 diabetes was previously considered an adult-onset disease, it is now clear that it
also occurs in children and adolescents as evidenced by a growing number of reports from many
countries world-wide.
Type 1 Diabetes
Type 1 diabetes
Autoimmune destruction of pancreatic ß-cells in islets of Langerhan
Pancreas inability to produce insulin
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Diabetes mellitus is characterized by chronic hyperglycemia (high blood glucose concentration) and high nefa (non-esterified fatty acid) concentration. Over time high blood glucose and nefa concentrations may lead to a variety of complications which impair quality of life and reduce life expectancy. Insensitivity to insulin (insulin resistance for a given concentration of insulin, less glucose is cleared from the blood cells). Usually found in obese or overweight adults. Was typically associated with obese adults age 40+, but is becoming much more frequent in children. While genes play a role, 80% preventable with healthy diet and pa (international diabetes. Lifetime risk of developing dm in us (born in 2000) Although type 2 diabetes was previously considered an adult-onset disease, it is now clear that it also occurs in children and adolescents as evidenced by a growing number of reports from many countries world-wide. Autoimmune destruction of pancreatic -cells in islets of langerhan.