MPB 8115 Lecture 10: 4a

Consider the cross: Ee ff Gg HH x Ee Ff gg HH (assume these are designations for genes that are inherited in a Mendelian fashion). What is the probability that a single offspring from this cross would be genotypically: ee Ff Gg HH or Ee ff gg HH?

1. Outline a diagnostic strategy for patients with suspected HH. Comment upon whether you consider a liver biopsy to be necessary for definitive diagnosis of classical HH.

There have been suggestions that population screening for HH is introduced in Australia. Do you support this initiative? Give reasons to support your decision.

HH = Hereditary Hemochromatosis