BIOL 483 Lecture Notes - Lecture 36: H2Afx, H2Afz, X-Inactivation
Document Summary
Want to control what is getting replicated and ensure things don"t get re replicated or replicated improperly. Canonical = rule during replication, variants are exceptions that are added when something happens during replication. Canonical histones since we need to make so many of them, they don"t have introns/ don"t need to be spliced, don"t need poly a tail, much faster to go from rna -> protein. Variants don"t need 5000 h2a. z in genome, they have introns and poly a tails like other genes so they get spliced and go through maturation process -> slower turnover from rna -> protein. Introns help in two ways: 1) make gene longer 2) needs to get cut during maturation process. When you cut out introns, would still be chromatinised and signals need ot happen but have more transcription but higher risk of cryptic transcription when you have a smaller gene.
