CHEM 451 Lecture Notes - Lecture 13: Partition Coefficient, Hydrophobicity Scales, Potassium Channel
Document Summary
Ions don"t spont go across membrane, small/ hydrophobic/ uncharged polar molecules have high permeability. Transporters and channels facilitate non spont molecules across membrane. Proteins whose role is to facilitate non spont molecules across membrane have low partition coefficients for membrane. For hydrophobicity scale, for partition, to what extent to certain resiques want to be in a polar vs non polar environment. Role is to transport non spontaneous molecule across membrane. High partition coefficient can transport easily, those that don"t will not. In free energy diagram, any molecule in absence of active transport process cross membrane by diffusion. Things that diffuse from high to low conc, can be limited by diffusion in absence of helper molecules. Solvation of molecules to pass because solvated molecule will solvate itself before going through. Ion channels and transporters lower energy barrier to make it more favourable for molecules to transfer through. Small hydrophobic uncharged molecules will cross membrane to some extent.
