BIOL 118 Lecture Notes - Lecture 17: Plasmodium Vivax, Plasmodium Falciparum, Mutation

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Change to recipe: change recipe change protein. Some can be minor while some can be devastating. Started in africa natural selection come on play. Rare mutation becomes more common w/ each generation** Mutation that eliminates ability to make duffy protein is favorable in area w/ malaria (p. vivax) Beneficial mutation if protein has no important function only for p. Idea: all ppl migrated out of africa. Either mutation occured after ppl migrated out of africa or ppl lost it once migrated out. Uses diff strategies/proteins to get into rbc. Occasionally can be good providing lucky advantage. Natural selection can only act after mutation occurs. Change the shape change the protein (ap bio) =all have two sets of chromosomes=2 diff versions of duffy gene (homozygous & heterozygous) Person w/ 2 mutations only person resistant to p. vivax (homo recessive) All 1 duffy protein (normal needed) for p. vivax to infect. 1 form of resitance^=why africans can be immune.

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