BIO 320 Lecture Notes - Lecture 6: Lipid Bilayer, Trypsin, Covalent Bond
Document Summary
Within certain membranes (e. g. , plasma membrane), there are micro-domains (~50 nm in diameter) especially enriched in sphingolipids and cholesterol. Because sphingolipids tend to have longer and straighter carbon chains, these lipid rafts tend to be thicker. Specific membrane proteins (including those with longer trans-membrane domains) are also enriched in lipid rafts. Some such proteins play important roles in cell signaling. Protein: 2 types: integral membrane proteins. Lipid-anchored proteins: covalent link of protein to a lipid or fatty acid, which inserts into membrane: peripheral membrane proteins. Two types of membrane proteins: integral and peripheral. There can be specific interactions between phospholipids and transmembrane domains. The functions of some proteins can be affected by these specific interactions. Lipid molecule(s) covalently linked to specific residues on proteins. 5 and 6 are lipid anchored (e. g. farnesyl and gpi anchors) 7 and 8 are peripheral membrane proteins.
