BIO 320 Lecture Notes - Lecture 11: Homeostasis, Cell Membrane, Cytosol
Document Summary
Lecture 11: traffic through the golgi and back to er. Most become n-linked glycosylated and undergo glucose trimming. Protein folding for all, and export of misfolded proteins back into the cytosol for poly-ubiquitination and degradation in the proteasome (so called er-associated degradation, or erad). Only properly folded proteins leave the er for the golgi. In many cell types, er-derived transport vesicles fuse with each other to form the vesicular tubular cluster, which becomes the cis-golgi (network) Specific proteins are concentrated in distinct golgi sub-compartments, including many enzymes that modify proteins that are on their way from the. Cgn to the tgn: forward moving (anterograde) copi-coated vesicles bud from each sub-compartment (e. g. , ) and fuse with the next sub- compartment (e. g. , ) to move proteins from the cgn to the. Tgn: selected proteins are packaged into backward moving (retrograde) copi-coated vesicles that bud from each sub- compartment (e. g. , ). Contents first found in cgn is now found in tgn.
