NEU 365D Lecture Notes - Lecture 8: Loading Dose, Bavarian State Library, Intravenous Therapy
Document Summary
Immediate effect is desired rapidly administer to fill body stores and establish c ss. Assume we are about to give a drug to a 70 kg man and that for this drug. C ss = 2 mg/l, t 1/2 = 1. 5 hr, and his body is 70% water. Cl = kv d = 0. 462 hr -1 x 49 l = 22. 64 l/hr. What is l? t 1/2 = 0. 693 / k k = 0. 93 / 1. 5 hr. 0. 7 l/kg x 70 kg = 49 l. Q = kv d c ss = 0. 462 hr -1 x 49 l x 2 mg/l = 45. 28 mg/hr. L = v d c ss = 49 l x 2 mg/l = 98 mg. Without loading dose: q (infusion rates) higher q leads to higher c ss. Rate of approach is only dependent on the elimination rate constant (k) & the amount of time passed.
