NEU 365D Lecture Notes - Lecture 18: Thymidylate Synthase, Angina Pectoris, Opioid Antagonist
Document Summary
Simultaneous usage of several therapeutic agents concurrently (prescribed, over the counter, etc. ) From food additives, insecticides, cleaning agents, cosmetics, etc. Administration of one drug change the effect of another enhance/diminish its effects at its site of action. Classification of drug interactions - based on consequence. I. e. combo drug therapy in cancer, antibiotic (for infection), hypertension, angina pectoris, etc. Ex: some cancer cells could be resistant to a class of drug give multiple classes to decrease the odds that it"ll be resistant to (all) given. Methotrexate (anti-cancer drug) effect negated by prior inhibition of thymidylate synthetase by 5-fluorouracil. Ex: cns depressants + ethanol greater sedating effect. Ex: naloxone (opioid receptor antagonist) diminishes the toxicity of the opioid. Overdose on opioids: i. e. heroin, morphine, etc. Cross bbb and metabolized to da by cells in the. Snc release into striatum to aid in movement. If l-dopa is metabolized peripherally requires higher doses. & acts competitively on enzyme that metabolizes l-dopa peripherally.
