NEU 365D Lecture Notes - Lecture 24: Hematopoietic Stem Cell Transplantation, Multiple Myeloma, Oral Mucosa
Document Summary
Some anticancer drugs act differently from other drugs (atypical from drugs) Ex: childhood leukemia - ~90% cure rate. Investigate the specifics of cancer for an individual and target your therapy. Principles of cancer chemotherapy: kill all clonogenic cells (identical clones that are able to replicate) Clonogenic cells have the potential to produce progeny to such an extent that results in the death of the host. Take up resources at an incredible rate, or grows into a bad area: fractional kill hypothesis. A constant fraction of cancer cells are killed with each round of chemotherapy (antineoplastic drug per unit time) Remaining cells are more resistant that the original cells. Kill of the more sensitive cells first. First round of drugs can be effective remission. When it comes back, can"t do anything more (resistant: steep dose-response curves. Drugs normally got from [threshold effect] to [maximal effect] over 2 log orders.
