PHARMACOLOGY Study Guide - Chloroform, Naltrexone, Flunitrazepam
Document Summary
Opiate: a drug derived from alkaloids of the opium poppy. Opioid: the class of drugs that includes opiates, opiopeptins, and all synthetic and semisynthetic drugs that mimic the actions of the opiates. Opioid peptides: endogenous peptides that act on opioid receptors. Opioid agonist: a drug that activates some or all opioid receptor subtypes and does not block any. Partial agonist: a drug that can activate an opioid receptor to effect a submaximal response. Opioid antagonist: a drug that blocks some or all opioid receptor subtypes. Mixed agonist-antagonist: a drug that activates some opioid receptor subtypes and blocks other opioid receptor subtypes. The opioids include natural opiates and semisynthetic alkaloids derived from the opium poppy, pharmacologically similar synthetic surrogates, and endogenous peptides. On the basis of their interaction with opioid receptors, the drugs are classified as: agonists, mixed agonist-antagonists, antagonists. Many of the pharmacologic actions of opiates and synthetic opioid drugs are effected via their interactions with endogenous opioid peptide receptors.
