PHARMACOLOGY Study Guide - Quiz Guide: Edema, Distal Convoluted Tubule, Ototoxicity
Document Summary
Drugs inducing a state of increased urine flow. Decrease the reabsorption of na+ at different sites ln the nephron. This segment carries out amino isosmotic reabsorption of acids, glucose, and numerous cations. It is also major site for sodium chloride and sodium bicarbonate reabsorption. The proximal tubule is responsible for 60-70% of the total reabsorption of sodium. Nacl currently available drug directly acts on reabsorption in the pct. Bicarbonate itself is poorly reabsorbed through the luminal membrane, but conversion of bicarbonate to carbon dioxide via carbonic acid permits rapid reabsorption of the carbon dioxide from co2 and. Sodium is separately reabsorbed from the lumen in exchange (nhe3 transporter) and transported into the interstitial space (na+/k+ atpase) for hydrogen ions. Carbonic anhydrase is the enzyme required for the bicarbonate reabsorption process on the brush border and in the cytoplasm, is the target of carbonic anhydrase inhibitor drugs. Active secretion and reabsorption of weak acids and bases also occurs in the pct.
