CMB 311 Study Guide - Quiz Guide: Carnitine O-Palmitoyltransferase, Acetyl-Coa, Mitochondrial Matrix

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Main site - mitochondria but also a portion occurs in the peroxisomes. Lipases (enzyme) catalyze hydrolysis of bonds between fatty acids and the rest of triacylglycerols. Fatty acid must be activated before transport by formation of acyl-coa (catalyzed by. Acyl-carnitine enters mitochondrial matrix by carnitine translocase across the mitochondrial inner membrane. Acyl-carnitine > acyl-coa by carnitine acyltransferase ii in the mitochondrial matrix. A series of reactions that cleaves carbon atoms 2 at a time" from the coa end of a fatty acyl-coa (from the carboxyl end of a fatty acid) Called beta-oxidation because the beta carbon of the fatty acid undergoes oxidation to a carbonyl group. Reaction 1: oxidation of the alpha, beta c-c single bond to a c-c double bond. Reaction 3: oxidation of beta-hydroxyl group a carbonyl group. Reaction 4: cleavage of carbon chain using another coa-sh. Beta oxidation of acyl chain nadh, fadh2. Beta oxidation is not the end of fatty acid oxidation.

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