CMB 311 Study Guide - Pyridoxal Phosphate, S-Adenosyl Methionine, Chorismic Acid
Document Summary
The precursors come from; glycolysis, tca cycle, and pentose phosphate pathway. Mammals can synthesis only about half of all amino acids. What molecule does alanine synthesis start from? (precursor) how about glutamate and. Not toxic for animals as we do do not have anzymes for chorismate biosynthesis. What molecules does histidine synthesis start from? (precursor) Levels of all amino acids must be balanced. Many amino acids share common precursors simple feedback inhibition could shut down the synthesis of several mino acids. The ribosse-phosphate unit in nucleotide comes from prpp. Prpp is the intermediate in the biosynthesis of nucleotides and histidine. Pyrimides bases are built as orotate, then add to prpp and modified to the final nucleotide. In purine biosynthesis, which molecule is the branch point ? (amp and gmp are synthesized from it) There is an accumulation of prpp with leads to excess synthesis.
