IMED1002 Final: IMED1002 Revision Notes 148
IMED1002 Revision Notes 148
Hierarchy for chromatin and chromosome
● DNA double helix
● Nucleosome core of 8 histone molecules
● From chromatosome
● Form chromosomes!
Changes in chromatin structure
● Epigenetic modifications
○ When done to histone proteins:
■ such as:
● Methylation
● demethylation
● Acetylation
● deacetylation
○ can alter the structure of chromatin
○ Results in:
■ transcriptional activation
■ Repression
● Chromatin is?
○ Complex of DNA and proteins
■ packed within the nucleus of eukaryotic cells
Eukaryotic transcription regulators
● Assemble into complexes on DNA
○ HOW?
■ Like prokaryotic cells
● eukaryotic cells also have mechanisms
○ to prevent transcription
