IMED2004 Study Guide - Final Guide: Genetic Screen, Linkage Disequilibrium, Gene Mapping
Document Summary
Trying to locate disease genes in genome. The identification of a gene based solely on its position in the genome. Most widespread strategy in human genetics in the last 15-25years. Very strong track record in single-gene disorders. Understanding of function not a certain outcome. Poor track record with multifactorial traits (complex disease) Even if locate gene, you might not know the function of genes. People who have similar phenotypic values (ie disease) should have higher chance than the expected levels of sharing of genetic material near the genes that in uence those traits. Measures the segregation of alleles and a phenotype within a family. Genes that are physically close together are more likely to be co-inherited. Genes that are physically far apart on the chromosome are less likely to be co-inherited. Detect over broad chromosomal regions on genome. Evaluate the evidence of a direct correlation between a marker allele and a disease risk allele.
