BIOL 1201 : Learning Objectives Number 3 (Exam 3)

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azuremammoth471

15 Mar 2019

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Be sure you can complete the worksheets on cell division. Review the material in the cell division summary sheet. Centromeres: region containing specific dna sequences where the chromatid is attached to sister chromatid. Kinetochores: structure of proteins associated with specific sections of chromosomal. Dna at each centromere: the 2 kinetochores face in opposite directions. Chromatids: entire complex of dna and proteins that is the building material of chromosomes. Chromosomes: a complex linear strand of dna and protein. Chromatin: the long linear strand of dna and complexed proteins. Spindle apparatus: segregates chromosomes between daughter cells during cell division, mitotic spindle, consists of fibers made of microtubules and proteins. It"s a control point where stop and go ahead signals report crucial cellular processes that should have occurred by that point, completed correctly, and whether or not the cycle should proceed. Haploid: cell that has one set of chromosomes. Diploid: cell that has 2 sets of chromosomes.

Related Questions

Part A- Microtubules. Select all that apply.

1) They are filaments in mitotic and meiotic spindles

2) They are required for moving sister chromatids to opposite sides of the poles during anaphase II of meiosis and anaphase of mitosis.

3) They are required for moving homologs to opposite sides of the poles during anaphase I of meiosis.

4) They are important for maintaining homologous chromosome pairing and plays a role in recombination.

5) They catalyze the phosphorylation of specific proteins.

6) They are a layered structue located between paired homologs in prophase I of meiosis in many organisms.

Part B- Cyclin-dependent kinases. Select all that apply.

1) They are filaments in mitotic and meiotic spindles.

2) They are enzymes that control progression through cell cycle.

3) They are required for the segregation of chromosomes during anaphase of mitosis or meiosis.

4) They are important for homologous chromosome pairing and plays a role in recombination.

5) They catalyze the phosphorylation of specific proteins.

Part C- Kinetochores. Select all that apply.

1) They are enzymes that control progression through cell cycle.

2) They are important for maintaining homologous chromosome pairing and plays a role in recombination.

3) They are required for the segregation of chromosomes during anaphase of mitosis or meiosis.

4) They are complx structures attached to the centromeres of chromosomes that bind to spindle microtubules.

5) They catalyze the phosphorylation of specific proteins.

Part D- Synaptonemal complex. Select all that apply.

1) It is required for moving sister chromatids to opposite sides of the poles during anaphase II of meiosis and anaphase of mitosis.

2) It is a layered structure located between paired homologs in prophase I of meiosis in many organisms.

3) It is complex structures attached to the centromeres of chromosomes that bind to spindle microtubules.

4) It catalyzes the phospohorylation of specific proteins.

5) It is important for maintaining homologous chromosome pairing and plays a role in recombination.

M2A1 Worksheet: Mitosis and Meiosis

A dog is a diploid organisms and has 39 pairs of chromosomes (2n = 78), where n = 39 chromosomes from each parent. Use this example to answer the following question regarding chromosomal number.

INTERPHASE

How many chromosomes are present in the somatic cell?

What do they look like?

What are they âdoingâ in G1 of this phase?

What is happening in the S phase?

What is happening in the G2 phase?

What follows G2 phase in a somatic cell?

What follows G2 phase in a gamete cell?

MITOSIS

Number of chromosomes in the parent cell.

Number of chromatids in the parent cell.

Number of chromosomes in the daughter cell.

Number of chromatids in the daughter cell.

How many daughter cells are produced?

Are the daughter cells haploid or diploid?

How many cell divisions take place?

In what type of cell does this division occur?

Meiosis 1:

Number of chromosomes in the parent cell.

Number of chromatids in the parent cell.

Number of chromosomes in each Meiosis I daughter cell.

Number of chromatids in each Meiosis I daughter cell.

Are the daughter cells haploid or diploid at the end of Meiosis 1?

Meiosis II:

Number of chromosomes in the âparentâ cell (which is a daughter cell from Meiosis I).

Number of chromatids in the âparentâ cell.

Number of chromosomes in each Meiosis II daughter cell.

Number of chromatids in each Meiosis II daughter cell.

Are the daughter cells haploid or diploid at the end of Meiosis II?

Which phase or phases of Meiosis account for the genetic variability among the daughter cells? Howâ¦ what happens in this phase to create the diversity?

Comparing Mitosis and Meiosisâ¦..

How many daughter cells result from Mitosis? Are they diploid or haploid?

How many daughter cells result from Meiosis? Are they diploid or Haploid?

Cell structures and function: Match each organelle to its function:

Organelle Function

Lysosome 1. Lipid synthesis

Rough ER 2. Houses DNA

Nucleus 3. Energy extraction

Smooth ER 4. Dismantles debris

Golgi apparatus 5. detoxification

Mitochondria 6. Protein synthesis

Peroxisome 7. Processes secretions

What is the function of checkpoint proteins in the cell cycle?

How can all of a personâs cells contain exactly the same genetic material, yet specialize as bone cells, nerve cells, muscle cells and connective tissues?

What are the 3 primary germ layers?

Briefly, in one or two sentences, distinguish between

a bacterial cell and a eukaryotic cell

interphase and mitosis

mitosis and apoptosis

an autosome and a sex chromosome

homologous pair of chromosomes and a sister chromatid

centromere and centriole

chromosome and chromatid

monozygotic and dizygotic twins

allele and gene

The bacterium E. coli, which is a major model system for the study of genes and DNA, has a singular circular chromosome of about 4x106 bp. In contrast, human diploid cells have __1__ chromosomes, of __2__ different types (donât forget that the X Â¹ Y!). The total amount of DNA found in a haploid cell such as a sperm or egg is called the organismâs âC-valueâ; the human C-value is __3__.

Also in contrast to the E. coli circular chromosome is the fact that eukaryotic chromosomes are not circular, but instead are __4__. Eukaryotic chromosomes are complexed heavily with protein to form a DNA-protein complex generically called __5__. The proteins found can be considered to fall into two general classes: __6__ and __7__. The first class is made up of 5 major proteins called __8__, __9__, __10__, __11__, and __12__. On a weight to weight basis, these proteins make up about __13__% of the total mass of a chromosome. Since these proteins must associate relatively non-specifically with DNA, they are rich in the basic amino acids __13__ and __14__, which gives the proteins a net __15__ charge.

One goal of packaging the DNA into chromatin is to compact the genome so it will fit into a nucleus. The basic unit of chromatin structure is the __16__, which has __17__ base pairs of DNA wrapped around a âcore particleâ composed of __18__ copies each of the core histones. Each nucleosome is separated by a stretch of âlinkerâ DNA so that the repeating unit is approximately 200 bp. Lets do a little arithmetic: If we consider that the nucleosome is approximately __19__ nm in diameter, that there is about 200 bp in this structure, and that 200 bp of DNA would normally occupy __20__ nm if stretched out straight (recall that each base is spaced about 0.34 nm from the next), we can see that the nucleosome alone allows for a __21__-fold compaction ratio.

The nucleosome structure is further compacted by histone __22__, which is not a part of the core particle. Instead, this histone __23__ (does what?) to cause the nucleosomal 10 nm fiber to condense into a higher-order structure referred to as the __24__ nm fiber. In the nucleus, chromosomes do not just float around freely: they are tethered to a proteinaceous structure called the __25__ at specific DNA regions called âSARsâ, which stands for __26__. SARs are rich in topoisomerases, to allow the winding and unwinding of the DNA that accompanies replication and transcription to occur, despite this constraint.

The 30 nm fiber discussed above is the form in which transcriptionally active DNA is believed to exist in the nucleus; however, further condensation leads to a highly condensed inactive form called __27__; in this terminology, the active form is referred to as __28__. The inactive condensed form can be divided into two types: one type is essentially invariant between cell types, and since it is âon all t timeâ, it is referred to as __29__. The other type comes and goes, depending on the expression of the genes present in that region of the chromosome; it is referred to as __30__.

Eukaryotic chromosomes carry the genes, of course, but also have other functional regions. One such region is the place where the spindle apparatus attaches during mitosis and meiosis; this region of the chromosome is called the __31__. Another important part of the linear eukaryotic chromosome is the ends; these are called __32__. In humans, the end of each chromosome is composed of many repeats of the short sequence __33__. One more type of functional region on each chromosome is the place where DNA replication starts; in humans, each chromosome has several of these __34__. Thus, eukaryotic chromosomes carry several different types of functional sequences, which together allow for their __35__ during S phase, __36__ during mitosis and meiosis, and the __37__ of their genes

BIOL 1201 : Learning Objectives Number 3 (Exam 3)

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