BIOL 1201 : Bio 1201 Exam 2 Notes
Document Summary
Stability of biological molecules: at high temps biological molecules, such as protein dna, break down rapidly. Regulation of enzyme activity: how are enzymes controlled, can they be turned on and off, modulation of activity, binding of ligands, covalent modification. Competitive enzyme inhibition: substrate and inhibitor compete fir binding to the active site of the enzyme, inhibitor is structurally similar to the substrate, most apparent at low (substrate) Noncompetitive enzyme inhibition: inhibitor binds at a site away from the substrate binding site, causes a conformational change in the enzyme, not overcome by increasing the (substrate) Allosteric enzyme regulation: other site , modulator (activator or inhibitor) binds to a site than the substrate binding site (active site, causes a conformational change of the enzyme which changes the activity. Cooperativity: oxygen binding to hemoglobin, 4 oxygen binding sites, binding alters the affinity for o2.