PCD 8117 Study Guide - Final Guide: Tooth Eruption, Enolase, Fluoride
3 Jan 2020
School
Department
Course
Professor
fluoride
inhibit agglutination
Stannous
competitively
Post-eruptive
Topical
Reduce bacterial
remineralization
solubility
Decrease
Systemic
Lecture #2 - Fluoride Mechanism of Action
1.
Define systemic and topical routes of administration and mechanisms of action of
fluoride in relation to the caries process.
o Mechanisms of fluoride action
▪
▪
Promote
▪
acid of enamel
growth and reduce acid production
o Fluoride Routes of Administration (systemic vs. topical) vs. Method of Action
(pre vs. post eruptive)
▪
– intentional ingestion
● Pre-eruptive method of action
▪
– external (not meant to be ingested)
● method of action
o Topical effects of fluoride – post-eruptive effect – MAJOR EFFECTS 75-80%
▪
Inhibits enolase activity resulting in inhibition of glucose transport into
cell, sugar translocation, and interferes with cellular phosphatases that
dephosphorylates sugar phosphates.
▪
Note – fluoride inhibition of enzymes is concentration dependent, mainly
sensitive to enolase.
▪
Fluoride has a high affinity to calcium and therefore can
of bacterial to plaque surface – though only
works, not NaF or CaF2.
▪
Summary: topically, fluoride reduces demineralization, enhances
remineralization, and acts as an anti-microbial.
o Systemic fluoride mechanism of action – pre-eruptive effects – minor (15-25%)
effects
▪
Developmental incorporation
▪
Action on tooth size and structure – necessary for the formation of
crystalline structure.
● F- action – decrease solubility by filling in voids (void theory)
created by two -OH’s and increase crystallinity by converting
calcium phosphate to hydroxyapatite.
●
▪
Shallower pits and fissures
o Many place have had substantial caries decline without community water
fluoridation (CWF) or dietary F- supplements due to topical F use (dentrifice,
gels, varnishes, etc.)
o As little as 0.1, 0.3, and 1.0ppm fluoride can decrease the rate at which an acidic
solution dissolves enamel.
o Classification of approximal lesions by depth
Note – difference in solubility is not a factor for caries.
Document Summary
Lecture #2 - fluoride mechanism of action: define systemic and topical routes of administration and mechanisms of action of fluoride in relation to the caries process, mechanisms of fluoride action solubility acid remineralization. Decrease: promote of enamel growth and reduce acid production, fluoride routes of administration (systemic vs. topical) vs. Post-eruptive method of action: topical effects of fluoride post-eruptive effect major effects 75-80% F- action decrease solubility by filling in voids (void theory) created by two -oh"s and increase crystallinity by converting calcium phosphate to hydroxyapatite. However, combining the snf2 dentrifice and 10% snf2 solution caused a synergistic effect: fluoride pre-eruptive vs. post-eruptive (after enamel has fully developed, pre-eruptive effect reduction in enamel solubility, post-eruptive promotes remineralization and inhibits demineralization. Inhibits glycolysis, production of polysaccharides necessary for adhesion, and kills cariogenic bacteria: cariostatic mechanisms of various forms of fluorides, water fluoridation pre-eruptive. Minimal/no reduction of enamel solubility: toothpaste post-eruptive. F- taken up directly by demineralized enamel.
