PCTH 201 Chapter Notes - Chapter 1: Pharmacokinetics, Hydrophile, Pharmacogenomics
2 Oct 2017
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However, some classes of drugs do not need a receptor for its effect (i. e. interact with bacteria itself) e. g. some antibiotics, antacids, diuretics. (for communication of the cell with the environment and specialized for drugs) e. g. g protein coupled receptor e. g. transcription factors in dna replication. Different receptors trigger different affects e. g. adrenalin & anti-adrenaline binds with many receptors to trigger effects in smooth muscle contraction & relaxation / transmitter release / heart muscle contraction etc. Effect: receptors are used by the body. Translating drug binding into biological response: receptors can be . By providing exogenous drugs takeover the receptor and modify how they communicate in the body. Drug has to be able to reach that receptor in the body (pharmacokinetics) Dependent on how the drug is administered (e. g. insulin will be broken down by oral route), hydrophilicity, charge, size etc: drugs can .
