PCTH 201 Chapter Notes - Chapter 3: Weak Base, Drug Metabolism, Aldh2
2 Oct 2017
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Must have some degree of hydrophobic character. And are salts of weak acids/bases: ph of environment (can shift to protonated or deprotonated form or stay in equilibrium) The henderson hasselbalch equation can identify how much of each form exists. ph = pka + log ([conjugate base] / [weak acid]) When passes by a region with a particular receptor that it has high affinity to. Free drug: can distribute to other parts of the body. Drugs are not designed to bind to protein. Just inherent property of drug (take into consideration for drug dosing) Weakly-protein bound drug would have a greater therapeutic effect. Most drugs are excreted in the urine (renal excretion) Different members of p450 enzymes, grouped into similar isozymes (similar catalyzing function) Disease state, physiological stage, diet, other medications can change predicted rate of metabolism. Inhibited enzyme activity: potentially toxic effect & lower therapeutic effect e. g. grapefruit cannot be taken with certain drugs.
