BIOL 4105 Chapter : BIOL 4105 Leishmaniasis 6 13 12
Document Summary
Lutzomyia as the genus in the new world: l. mexicana in northern dallas in 2007. Africa, asia, europe: morphology, only two stages,a promastigote and amastigote. The promastigote is the form found in the sandfly, the infective stage for humans. Once it gets into humans it transforms into the amastigote, the replicating form. T. cruzi will partially retransform to the typomastigote because it is the infective stage for the vector: promastiigote is taken into a macrophage and turns into an amastigote, a leishman-donovan body is an amastogote form of this. If they get phagocytozed bu a neutrophils they die. I they get phagocytozed by the macrophage they are fine. They avoid the killing mechanisms of the macrophage and set up shop. Leishmania species is he macrophage of the host. Rupture out after being phagocytosed: sandfly eats blood with infected macrophages in it. The amastigotes turn into promastigotes in the fly"s gut.
