CHEM 2262 Chapter : Chapter 21 Pages 1 6
Document Summary
Amines are organic nitrogen compounds, formed by replacing one or more hydrogen atoms of ammonia (nh3) with alkyl groups. Amines are classified as primary (1 ), secondary (2 ), or tertiary (3 ) based on the number of alkyl groups bonded to the nitrogen atom. Heterocycles are cyclic structures where there is one or more heteroatom (i. e. , atom other than carbon) contained within the ring. Names of a few of the more common nitrogen-containing rings are shown below. In nomenclature and discussion of regioselectivity, rings are numbered with the heteroatom at position 1. Amines are present in many important biologically active compounds produced by plants and animals (natural products) or synthesized by pharmaceutical companies. Unless part of a delocalized system, a nitrogen with three single bonds is sp3 hybridized and has pyramidal geometry. If the nitrogen lone pair is part of a delocalized system (as in amides, enamines, anilines, pyrroles, etc.
