AH 3121 Chapter Notes - Chapter 8: Lectin, Immunoglobulin M, Helminths
Document Summary
Avery welch ah 3121 immunology week 9 chapter 8 notes 10/28/15. Opsonization & phagocytosis: ab coat microbes (opsonization) and promote ingestion (phagocytosis) Certain isotypes of ab bind to high affinity receptors which are expressed on neutrophils & macrophages. Various fc receptors found on immune cells: fc-gamma-ri (cd64) Functions in phagocytosis & activation of phagocytes: fc-gamma-riia (cd32) Avery welch ah 3121 immunology week 9 chapter 8 notes 10/28/15: fc-gamma-riib (cd32) Functions in feedback inhibition of b cells: fc-gamma-riiia (cd16) Functions in ab-dependent cellular cytotoxicity (adcc: fc-epsilon-ri. Functions in activation (degranulation) of mast cells and basophils. Antibody-dependent cellular cytotoxicity (adcc: nk cells can bind to ab-coated microbes and destroy them. Granules are discharged and contents kill: eosinophils work on helminth infections. Worms are resistant to microbicidal substances from neutrophils & macrophages. High affinity receptors for ige on eosinophils. Pathways of complement activation: not all types of ab will induce complement activation. Igg and igm do: alternative pathway, lectin pathway.
