NURS 3100 Chapter Notes - Chapter 11: Phenobarbital, Provitamin, Chronic Kidney Disease
Document Summary
Drug interactions 2: drug food and drug nutrient interactions. Drug-food and drug-nutrient interactions are very common. Some medications may be taken without consideration of timing with respect to food, some must be taken only in the fasting state, and some must be taken with food to maximize bioavailability. One of the most challenging issues facing nurses caring for multiple patients taking multiple drugs is how to properly schedule po (oral) medication administration with respect to food intake. The nutritional status of an individual can affect both the pharmacokineticsand the pharmacodynamics of drugs. Also, many drugs (including over-the-counter agents, alcohol, and tobacco) can alter nutritional status. Adequate nutritional status is essential for optimal po drug absorption. Protein and calorie malnutrition can reduce the villous absorptive surface area of the intestine (shown in the figure). The absorption of drugs, vitamins, and minerals will be decreased as a result.
