BIOL 3060 Chapter x: Chromatin Remodeling
Document Summary
Occurs by relaxing (opening up) chromatin structure prevents binding of transcription factors, activators, and polymerase helical dna tightly coils to form octamers chromatin structure represses gene expression chromatin remodeling (through chromatin remodeling complexes) covalent modification of histones. Dna must unwind in order for transcription to take place. In the nucleus, histone proteins associate to form octamers. chromatin structure changes and the dna becomes more accessible to the transcriptional machinery. Major points of controls are: chromatin condensation transcription initiation. Rna stability, translation and transcription (through rna interference) post-translational modifications. Before transcription can occur, dna must be made accessible to transcription factors. The link between transcriptional activators and chromatin condensation. Chromatin condensation control and transcriptional regulation are intertwined in chromatin certain transcription factors and other proteins that regulate transcription either have acetyl transferase activity or attract acetyltransferases to dna. Uv light creates covalent bonds between dna and protein.