BIO 315H Chapter : LO Lecture 21-Mutation.pdf
Document Summary
Scientists use mutation as a tool to study gene function. Mutations are also the causes of evolution of organisms. Although mutations are at the heart of genetic studies, general public are becoming increasingly aware of the causes and consequences of mutations as many mutations lead to cancer. Learning goals: we will learn various classifications of mutations. At the phenotypic level, we categorize mutants as loss-of-function, gain-of-function mutants. These classifications also include suppressor mutants that can be either intragenic or intergenic suppressor that suppresses the original mutant phenotype. Other broad classification includes forward mutants or reverse mutants. Yet more physical classification includes substitution, deletion, insertion and translocation mutations. You will learn how to distinguish them and what s the consequence for each of these types of mutations: we will discuss various sources of mutations, mutagens and how they cause mutation in a. Dna sequence: finally you will learn how to test whether a chemical is a mutagen or not.
