BIO 315H Chapter : LO Lectures 25 & 26-Prok gene regulation.pdf
Document Summary
Although prokaryotes have simple transcriptional machinery, their transcription is also highly regulated. They are typically responding to the presence of a nutrient or environmental condition. Because they don"t have too much reserve energy or can"t afford to waste energy, their transcriptional machinery needs to respond very quickly to changes in nutrient availability or environmental conditions. To fine tune transcription in response to these signals, prokaryotes have developed diverse regulatory mechanisms that suits their needs. Learning goals: regulation of gene expression occurs at multiple stages in both prokaryotes and eukaryotes. These include gene organization (mostly in prokaryotes), chromatin structure (mostly in eukaryotes), transcriptional regulation, mrna stability, translational regulation, post- translational modifications and protein stability. Of all these, transcriptional regulation is the most dominant form of regulation in gene expression in both prokaryotes and eukaryotes: you should be able to make a distinction between core transcription factors, regulator proteins, and their binding sites.
