PHTY300 Lecture Notes - Lecture 16: Mechanical Ventilation, Sleep Apnea, Apnea
Document Summary
Discuss the effects of sleep on respiration in the normal subject: why we sleep, cellular repair/prophylactic maintenance, metabolic functions and energy balance, removal of toxic substances and metabolic waste, consolidation of newly acquired neural information. Sleep and health: no less important than diet & activity, sleep loss associated with poorer health outcomes, risk of cv disease, diabetes, obesity, neurocognitive impairment, cancer risk, overall mortality. It provides a splinting pressure to maintain airway patency: central sleep apnoea, heavy breathing then sudden pause, crescendo decrescendo, pause - no effort (instead of obstruction, etc. ) > no signals from the brain: rapid breathing decreases co2, signals from brain start when co2 rises again, seen in: Severe congestive heart failure 30% of patients. Impaired, damaged or depressed: sleep increases the risk of hypoventilation because, reduced central respiratory drive, postural muscle hypotonia, upper airway resistance, dependence on the diaphragm, reduced chemo-responsiveness to o2 and co2.
