BIOL2117 Lecture Notes - Lecture 6: Nuclear Lamina, Nuclear Pore, Nuclear Membrane
Document Summary
Ins and outs of the nucleus key points. The nucleus is surround by a double membrane nuclear envelope; the nuclear lamina is an important structural component. Nucleus is the site of transcription and ribosome subunit assembly. The nucleus facilitates the separation of translation from transcription; more sophisticated means of gene regulation and response to environmental cues (e. g. nf-kb pathway) Proteins and mrna translocate across nuclear envelope at nuclear pore complexes, bound by proteins with specific roles in translocation of these proteins/mrna. Early eukaryotes (pre-leca) evolved proteins that could curve membranes; cause invaginations of the plasma membrane. These invaginations became the endomembrane system; formed around cellular dna to become nucleus. Possibly why the nuclear membrane is a part of the endomembrane system. Membrane curving proteins diversified to become coat proteins at various organelles, and structural components of npc. Either clathrin coated or the y-protein - this is how it diversified.
