BMS291 Lecture 4: Week 4 Notes
Document Summary
Excludes tumours in the lungs of other origin e. g. sarcomas, lymphomas, mesotheliomas. In women, deaths due to lung cancer exceed those of breast cancer. Surge in women smoking in 1970-80s whilst numbers of men smoking has declined. Types of lung cancer non-small cell carcinoma. Typically located near hilum and projecting into bronchi. Tumours arises from the glands; more often in peripheral regions. Types of lung cancer small cell carcinoma. Inactivation of tumour suppressor genes or loss of p53. Epithelial metaplasia in situ carcinoma invasive carcinoma metastasis. Signs & symptoms may be first indicators of scc. Survival is 1-3 months from diagnosis if untreated. Poorly differentiated cells have more abnormalities and the tumour will have high numbers of these. Bms291 lecture notes - 201830 abnormal cells e. g. too much dna (chromatin) Changes to size and shape of the nucleus or the cell. Target metabolic pathways exploiting the difference between normal and abnormal cells (minimizing adverse effects)
