EHR522 Lecture Notes - Lecture 9: Kidney Disease, Cardiorespiratory Fitness, Skeletal Muscle
Document Summary
Week 9: evidence for the efficacy of exercise to treat. Summary of evidence: aerobic exercise, resistance exercise, combined exercise. Effect of exercise on other health outcomes. 70% of normal at early stages of ckd to 50% when beginning dialysis. Cause of physical decline: renal anaemia and skeletal muscle dysfunction main causes of physical decline, cause fatigue, anemia can be treated with epo but: Weakness in proximal muscle groups and lower extremities. Evidence for exercise: benefits of exercise have been explored for past 30 years, some demonstrating improved: Reduced cvd risk: but very little actual evidence as to efficacy, particularly in early stage, higher functioning kidney disease, most research based on end-stage kidney disease, few studies examining stages 2-4. Why is vo2 peak important: exercise capacity has an independent association with mortality risk across almost all chronic disease. What about inflammatory markers: ckd is characterised by a dominance of pro-oxidative systems and subsequently increased oxidative stress, resulting in:
