GMED2000 Lecture Notes - Lecture 1: Amoxicillin, Metoclopramide, Antipyretic
17 Jul 2018
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Document Summary
Pharmacodynamics: the way drugs act on the body. Agonist: chemical that binds to a receptor and activates the receptor to produce a biological response (enhancer) Antagonist: blocks the action of the agonist and causes an action opposite to that of the agonist (blocker) Pharmacokinetics: how the body handles the drug. Absorption: the process by which an unchanged drug proceeds from the site of administration into the blood: factors influencing drug absorption, cell membrane, blood flow, solubility of the drug, formulation. Ionisation: factors affecting drug absorption, oral, parental, topical. Genetics: if one enzyme is responsible for the breakdown of that drug and if there is a mutation in the gene responsible this then leads to a drug being metabolised differently. Environmental factors : diet, smoking (all impact enzyme activity) Disease states: heart failure reduces perfusion and therefore availability of enzymes, liver failure.
