HUMB1001 Lecture Notes - Lecture 2: Elastic Cartilage, Chondroblast, Chondrocyte

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12 Jun 2018

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How is the body supported?

What is connective tissue?

1. Abundant

2. Makes up every organ in the body

3. Consists of cells separated from each other by an abundant extracellular matrix

Connective Tissues

1. Bones

2. Cartilage

3. Tendons

4. Ligaments

Functions of connective tissue

1. Connects tissues to one another (tendons – muscle to bone, ligaments bone to bone)

2. Support moving parts of the body (bone – rigid support, cartilage – semi rigid support)

3. Protection (bone protects underlying tissue from damage)

4. Store compounds (bones store minerals – calcium, phosphate. Adipose store triglycerides)

5. Enclosed and separate tissue (sheets of tissue around connective tissue – periosteum)

Six major functions of the skeletal system

1. Support

2. Protection

3. Assistance with movement

4. Mineral homeostasis

5. Blood cell production

6. Triglyceride storage

Cartilage

Cartilage is made up of matrix (non-cellular substance consisting of non-fibrous proteins and other

molecules, such as proteoglycans) and fluid produced by chondroblasts.

1. A dense network of collagen fibres and elastic fibres

2. Chondrocytes within spaces called lacunae

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Key feature of cartilage

1. Avascular (no blood supply)

2. No nerves

3. Cartilage cells are formed from cells in the perichondrium and these cells produce the

cartilage matrix

How does cartilage grow?

1. Appositional growth – cartilage added to the outside of the existing cartilage

2. Interstitial growth – chondrocytes within the matrix divided and add more matrix between

the chondrocytes

Types of Cartilage

1. Hyaline

2. Fibrocartilage

3. Elastic cartilage

Hyaline Cartilage

❖ Consists of specialized cells the chondroblasts that produce the matrix. When the

chondroblasts become surrounded by matrix they change their name and are called

chondrocytes. Chondrocytes are located in spaces called lacunae

❖ Matric

❖ Perichondrium

❖ Articular cartilage

Bone

How does bone matrix form?

Osteoblasts

❖ Formation of bone through ossification or osteogenesis

❖ Collagen is produced by E.R. and golgi. Released by exocytosis

❖ Precursors of hydroxyapatite stored in vesicles, then released by exocytosis

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Role of collagen in bone tissue?

❖ Organic: collagen and proteoglycans

❖ Inorganic: hydroxyapatite

If mineral removed, bone is too bendable

If collagen is removed, bone is too brittle

Types of bone growth

What is the embryonic precursor cell and tissue of bone?

Mesoderm and mesenchymal tissue

At about 13-14 days the developing foetus forms an embryonic disc with 3 layers of cells.

1. Outer layer – ectoderm (epidermis of skin)

2. Middle layer – mesoderm (bones except facial). This tissue is called mesenchyme

3. Inner layer – endoderm (inner lining of the digestive system)

What is the embryonic precursor of tissue and cells forming intramembranous ossification?

➔ Occurs in mesenchymal cells within connective tissue such as the tissue surrounding the

developing brain

➔ Mesenchymal cells differentiate into osteoprogenitor cells

➔ These differentiate into osteoblasts

➔ The osteoblasts form the woven bone matrix, eventually either trabeculae or the outer layer

of lamellar compact bone

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Document Summary

What is connective tissue: abundant, makes up every organ in the body, consists of cells separated from each other by an abundant extracellular matrix. Adipose store triglycerides: enclosed and separate tissue (sheets of tissue around connective tissue periosteum) Six major functions of the skeletal system: support, protection, assistance with movement, mineral homeostasis, blood cell production, triglyceride storage. Cartilage is made up of matrix (non-cellular substance consisting of non-fibrous proteins and other molecules, such as proteoglycans) and fluid produced by chondroblasts: a dense network of collagen fibres and elastic fibres, chondrocytes within spaces called lacunae. Key feature of cartilage: avascular (no blood supply, no nerves, cartilage cells are formed from cells in the perichondrium and these cells produce the cartilage matrix. How does cartilage grow: appositional growth cartilage added to the outside of the existing cartilage. Interstitial growth chondrocytes within the matrix divided and add more matrix between the chondrocytes. Types of cartilage: hyaline, fibrocartilage, elastic cartilage.

Related Questions

Question 1.1. (TCO 1) Moving from the elbowtoward the wrist is an example of moving in a _____ direction.(Points : 4)

distal
lateral
medial
proximal

Question 2.2. (TCO 1) The left and rightpleural cavities are part of this cavity. (Points : 4)

Abdominal
Pelvic
Dorsal
Thoracic

Question 3.3. (TCO 1) The _____ separatesanterior and posterior portions of the body. (Points : 4)

transverse plane
sagittal plane
parasagittal plane
frontal plane

Question 4.4. (TCO 1) A parasagittal plane_____. (Points : 4)

separates superior andinferior portions of the body
separates right and leftportions of the body
misses the midline,separating right and left portions of unequal size
separates anterior andposterior portions of the body

Question 5.5. (TCO 1) Which of the followingterms is not used to define the structure that separatesthe contents of a human cell from its surrounding medium? (Points :4)

Cell wall
Cell membrane
Plasma membrane
Plasmalemma

Question 6.6. (TCO 1) Approximately 60-80% ofa living cell is made up of _____. (Points : 4)

water
oxygen
lungs
potassium

Question 7.7. (TCO 2) Stratified cuboidalepithelia would be found _____. (Points : 4)

lining the urinarybladder
lining the ducts thatdrain sweat glands
lining kidneytubules
lining the stomach
at the surface of theskin

Question 8.8. (TCO 2) The layer of theepidermis that contains stem cells undergoing mitois is the _____.(Points : 4)

stratum corneum
stratum basale
stratum granulosum
stratum spinosum

Question 9.9. (TCO 2) The tissue that alwayshas a free surface exposed to the internal or external environmentis the _____. (Points : 4)

epithelial tissue
connective tissue
muscle tissue
neural tissue

Question 10.10. (TCO 2) The code to make aparticular protein is a gene located on a _____. (Points : 4)

tDNA molecule
RNA molecule
DNA molecule
tRNA molecule

Question 11.11. (TCO 2) The lipid bilyaer ofthe plasma membrane is constructed largely of _____ with smalleramounts of cholesterol and glycolipids. (Points : 4)

cholesterol
neutral fats
phospholipids
fat-soluble vitamins

Question 12.12. (TCO 2) A group of similarcells and their intercellular substances specialized to perform aspecific function is a(n) _____. (Points : 4)

cell
tissue
organ
atom

Question 13.13. (TCO 3) The _____ of sweat isproduced by the action of bacteria feeding on the sweat. (Points :4)

color
odor
salt
nitrates

Question 14.14. (TCO 3) An acquired skindisease resulting in irregular patches of skin of various sizes andcompletely lacking pigmentation is known as _____. (Points :4)

albinism
impetigo
vitiligo
ringworm

Question 15.15. (TCO 3) Squamous cellcarcinoma arises from this layer of the skin. (Points : 4)

Stratum spinosum
Stratum corneum
Stratum granulosum
Stratum basale

Question 16.16. (TCO 3) The primary purpose ofsensible perspiration is _____. (Points : 4)

to heat internal bodyorgans
to heat the skin
for evaporativecooling
to get rid of bodywaste
to elevate bodytemperature

Question 17.17. (TCO 3) Sweating is anevaporation process that _____ the body. (Points : 4)

cools
heats
has no effect on
dries the body

Question 18.18. (TCO 3) When the _____ musclecontracts, it causes the hair to stand on its end. (Points :4)

vellus
terminal hair
rrrector pili
arrector pili

Question 19.19. (TCO 4) The formation of redand white blood cells by the red bone marrow is known as _____.(Points : 4)

hematopoiesis
periostesis
mastication
cartilage

Question 20.20. (TCO 4) Yellow bone marrowcontains a large percentage of _____. (Points : 4)

fat.
blood-formingclots.
elastic tissue.
Sharpey's fibers.

Question 21.21. (TCO4) The shaft of a longbone is called the _____. (Points : 4)

physis
epiphysis
diaphysis
metaphysis
lamella

Question 22.22. (TCO 4) The boundaries betweenskull bones and between immovable joints are _____. (Points :4)

foramina
fontanels
lacunae
sutures

Question 23.23. (TCO 4) The _____ is theexpanded prominence of the upper hip bone. (Points : 4)

sacrum
coccyx
pubis
iliac crest

Question 24.24. (TCO 4) The _____ is afibrovascular membrane that covers a bone. (Points : 4)

endosteum
yellow bone marrow
periosteum
compact bone marrow

Question 25.25. (TCO 5) The bones that formthe wrist are the _____. (Points : 4)

carpals
tarsals
metatarsals
phalanges

Question 26.26. (TCO 5) The following isnot
a structure found on the ishium. (Points : 4)

Superior ramus
Inferior ramus
Lesser sciaticnotch
Superior body

Question 27.27. (TCO 5) The side walls of thevertebral foramen are formed by the _____. (Points : 4)

centrum of thevertebrae
spinous process
pedicles
laminae

Question 28.28. (TCO 5) The largest facialbones are the _____. (Points : 4)

palatine bones
nasal bones
lacrimal bones
maxillary bones

Question 29.29. (TCO 5) The bone in directcontact with the first metatarsal (big toe) is the _____. (Points :4)

medial cuneiform
lateral cuneiform
cuboid
calcaneus

Question 30.30. (TCO 5) The antebrachium iscomposed of which of the following two bones? (Points : 4)

The radius and theulna
The humerus and theclavicle
The scapula and theclavicle
The humerus and theradius

Question 31.31. (TCO 6) A joint united bydense fibrocartilaginous tissue that permits a slight degree ofmovement is a _____. (Points : 4)

suture
syndesmosis
symphysis
gomphosis

Question 32.32. (TCO 6) Articular cartilagefound at the ends of the long bones serve to _____. (Points :4)

attach tendons
produce red blood cells(hemopoiesis)
provide a smooth surfaceat the ends of synovial joints
form the synovialmembrane

Question 33.33. (TCO 6) The cruciate ligamentsof the knee _____. (Points : 4)

tend to run parallel toone another
also are calledcollateral ligaments
prevent hyperextension ofthe knee
assist in defining therange of motion of the leg

Question 34.34. (TCO 6) Menisci refer to_____. (Points : 4)

cavities lined withcartilage
small sacs containingsynovial fluid
semilunar cartilagepads
tendon sheaths

Question 35.35. (TCO 6) Synovial fluid ispresent in joint cavities of freely movable joints. Which of thefollowing statements is true about this fluid? (Points : 4)

It contains onlyenzymes.
It contains lacticacid.
It contains hyaluronicacid.
It contains hydrochloricacid.

amaranthworm158

[email protected]

Tue 9/19/2017 4:17 PM

To:

[email protected];

Here is the exam review for our next major lecture exam which will be on Monday. Notice that there are a few things missing, such as endochondral ossification. These will be added so just because it does not show up on this exam review doesn't mean you shouldn't study it. That being said, the details of each and every bone which I've gone over in lecture will be on the lab practical rather than the written lecture exam.

Anat 1, Exam 2. Spr 2016 LASC Name:____________________________________________________

1) A synarthrosis: a) is filled with synovial fluid. b) allow for a wide range of movement. c) includes the squamosal suture. d) is exemplified by the shoulder. e) all of the above.

2) Bursae: a) are located in the right atrium. b) are like elastomeric shock absorbers. c) are found in skeletal muscle fibers. d) form the sarcoplasmic reticulum. e) none of the above.

3) Irregular bones: a) can act like cams. b) can provide sites for muscle attachment. c) can protect soft-tissue organs. d) can act as levers. e) all of the above.

4) Condyles: a) are smooth articular surfaces. b) allow blood vessels to enter the bones. c) occur beneath the nail body after an injury. d) are produced by infected sebaceous glands. e) none of the above.

5) A head: a) is where you will find hyaline cartilage. b) is a smooth articular surface. c) is where a bone meshes with another bone. d) all of the above. e) none of the above.

6) Which of the following is the proper sequence of things following a bone fracture: a) hematoma, fibrous callus, bony callus, remodeling. b) hematoma, bony callus, fibrous callus, remodeling. c) hematoma, remodeling, fibrous callus, bony callus. d) hematoma, remodeling, bony callus, fibrous callus. e) fibrous callus, bony callus, remodeling, hematoma.

7) A diaphysis: a) contains yellow bone marrow. b) contain a lot of spongy bone tissue. c) occurs at the ends of long bones. d) all of the above. e) none of the above.

8) Short bones: a) protect underlying soft tissue organs. b) include the ribs. c) include the cranial bones of the skull. d) transfer mechanical forces. e) all of the above.

9) Fibrous joints: a) contain cruciate ligaments. b) include the pubic symphysis. c) are typically found in third class levering systems. d) include the lambdoid suture. e) all of the above.

10) Which of the following doesnât belong? a) tibiofibular joint. b) dentino-alveolar joint.
c) intervertebral disc. d) radioulnar articulation. e) cartilage.

11) Which of the following doesnât belong? a) atlanto-occipital joint. b) humero-ulnar joint. c) frontal suture d) acromio-humeral joint. e) tibiotarsal joint.

12) Hyaluronic acid: a) forms the extracellular matrix. b) is found in fibrous joints. c) keeps cartilage soft and pliable. d) is found in synostoses. e) none of the above.

13) First class levers: a) include the tibio-tarsal joint. b) have the effort between the fulcrum and the load. c) are like a teeter-totter. d) all of the above. e) none of the above.

14) Synchondroses: a) are typically synovial joints. b) allow for very limited movement. c) include sutures and gomphoses. d) are encased in synovial capsules. e) none of the above.

15) Parallel muscles: a) have long excursions. b) include the abdominal muscles. c) have excellent endurance. d) have low strength. e) all of the above.

16) Sphincteral muscles: a) enclose openings or passageways. b) are used when you talk.
c) surround the eyes. d) include the orbicularis oculi. e) all of the above.

17) Pennate muscle architecture: a) is typified by the pectoralis major. b) have high endurance.
c) generates high strength. d) has a longer excursion. e) all of the above

18) Endomysium: a) consists of dense fibrous connective tissue. b) surrounds each fasciculus.
c) surrounds bundles of muscle cells. d) all of the above. e) none of the above.

19) Cartilage: a) heals quickly if it is damaged. b) forms the lining of blood vessels. c) is found on the articular surfaces of bones. d) is a type of epithelial tissue. e) none of the above.

20) A tuberosity: a) is a hollow opening. b) is a shallow smooth articular surface. c) is a raised area that adjoins a condyle. d) is a larger outwardly curved articular surface. e) is a raised, rough-textured area.

21) Which of these doesnât belong? a) tuberosity b) trochanter c) condyle d) tubercle e) lunula

22) Epimysium: a) wraps around the entire muscle. b) is made of dense fibrous connective tissue. c) is continuous with tendons. d) all of the above. e) none of the above.

23) Which of the following is more likely to be an insertion rather than an origin? a) ulna.
b) cervical vertebra. c) thoracic vertebra. d) rib. e) Ischium.

24) Which of the following is more likely to be an origin rather than an insertion? a) clavicle.
b) tibia. c) radius. d) ulna. e) metatarsal.

25) Myofibrils: a) are composed of many muscle fibers. b) are composed of many muscle cells.
c) are composed of many sarcomeres. d) form the endomysium. e) all of the above.

26) Myosin: a) helps keep muscle cells from overstretching. b) is a protein. c) joins thin filaments together. d) forms part of the z-disc. e) all of the above.

27) Sarcolemma: a) surrounds the entire muscle organ. b) surrounds the endomysium.
c) is the cell membrane of a muscle fiber. d) surrounds the epimysium. e) none of the above.

28) Thin filaments: a) are made of titin. b) are pulled on by the thick filaments during contraction.
c) create the molecular âpower-strokeâ. d) all of the above. e) none of the above.

29) A second class lever: a) is like a wheel barrow. b) is like a teeter-totter. c) describes the humeroulnar joint. d) describes the atlanto-occipital joint. e) none of the above.

30) A sarcomere: a) is the basic unit of muscle function. b) is made mostly of proteins. c) shortens during a contraction. d) delivers an âall or noneâ response. e) all of the above.

31) Fast glycolytic fibers: a) have excellent endurance. b) deliver lots of power.
c) are more reddish in color than oxidative fibers. d) none of the above. e) all of the above.

32) Which of the following doesnât belong? a) Vastus lateralus. b) Vastus intermedius. c) Vastus medialis. d) Rectus Femoris. e) Gluteus minimus.

33) Which of the following doesnât belong? a) Teres major. b) Teres minor. c) subscapularis.
d) infraspinatus. e) supraspinatus.

34) Tendon sheaths: a) are filled with synovial fluid. b) can be likened to brake and shifter cable sheathing on a bike. c) are found around the carpal bones. d) really make life unpleasant if they get inflamed. e) all of the above.

35) Epithelial tissues: a) function in movement. b) conduct electrical impulses. c) form a structure for attachment of other organs. d) form barriers and walls. e) all of the above.

36) Elastic connective tissue: a) is found in bone. b) lines the inside of the trachea. c)Is found in small blood vessels like capillaries. d) is found in large arteries. e) all of the above.

37) Cartilage: a) heals quickly if it is damaged. b) forms the lining of blood vessels. c) is found on the articular surfaces of bones. d) is a type of epithelial tissue. e) none of the above.

38) Dense regular connective tissue: a) is poorly vascularized. b) heals slowly if at all. c) forms tendons and ligaments. d) can look a lot like smooth muscle under the microscope. e) all of the above.

39) Transitional epithelium: a) lines the urinary bladder. b) lines the blood vessels. c) contains cilia. d) joins the epidermis to the dermis. e) none of the above.

40) Skeletal muscle: a) responds to conscious thought. b) is found in the heart. c) is found in the walls of blood vessels and the GI tract. d) is composed of very small cells. e) all of the above.

For the following matching questions, each choice is used only once.

41) Fibroblast a) maintains bone tissue
42) Mast Cell b) secretes mucus
43) Chondrocyte c) responsible for inflammation response
44) Osteocyte d) makes collagen fibers
45) Goblet Cell e) maintains cartilage

For the following true-false questions, mark âAâ for true and âBâ for false.

46) Simple cuboidal epithelium is lines the trachea and Fallopian tubes/oviducts.
47) Elastic cartilage joins the ribs to the sternum.
48) An insertion is the more movable point of muscle attachment.
49) Tendons connect muscle to muscle or bone to bone.
50) Ligaments connect muscle to bone.
51) Transverse tubules allow nutrients to be dispersed throughout very large muscle cells.
52) Muscle twitch occurs when only a few muscle cells in the entire muscle are fully contracted.
53) Slow oxidative fibers have poor strength but excellent endurance.
54) Muscles can lengthen under their own power as well as contract.
55) Pottâs fracture is typical of skateboarders.
56) An incomplete fracture is a complete break through the entire bone.
57) Tetanus is the recruitment of additional fibers during muscle contraction.
58) Menisci are like elastomeric shock absorbers.
59) Diarthrotic joints allow for little to no movement.
60) A belly is the contractile portion of a muscle.
61) Synergistic muscles work with each other.
62) Muscle tissue, like your lab instructorâs evil twin before his morning coffee, is irritable.

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HUMB1001 Lecture Notes - Lecture 2: Elastic Cartilage, Chondroblast, Chondrocyte

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