PATH1001 Lecture Notes - Lecture 4: Hyaline Cartilage, Synovial Joint, Synovial Fluid
Document Summary
Synovial membrane: there are 2 types of synoviocytes: A=phagocytic to maintain synovial fluid integrity (macrophage like) B=secretory to produce synovial fluid (fibroblast like: function of synoviocytes: Assist in maintain homeostasis within the environment of the whole joint. Function of synovial membrane: synoviocytes of sm are main source of synovial fluid and key components that contribute to the unique functional properties of articular surfaces and modulate chondrocyte activity. They help maintain integrity of articular cartilage surface in synovial joints. They reduce friction by providing boundary lubrication at the articular surface: synovial fluid is the key medium for inhibition (nutrient exchange) Function of articular cartilage: frictionless motion between joint surfaces, even distribution of joint load, dissipates energy associated with loading. If all are optimal than cartilage longevity will be maximized. Composition of ac: cells-chondrocytes (1-2%, extracellular matrix-needed for maintenance of ac. Ac homeostasis: under normal conditions ac matrix is subjected to a dynamic remodeling process driven by different stresses.
